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Whoopi Goldberg and the Muppets.
Whoopi Goldberg has appeared on Sesame Street, Muppets Tonight and has shared the screen (and banter) with various Muppets on Hollywood Squares. She also provides the voice-over to a special intro for Sesame Workshop's international and educational efforts at the beginning of several home videos starting in 2004.
In 1994, she appeared on the Sesame Street's All-Star 25th Birthday special.
In the 2002 TV movie It's a Very Merry Muppet Christmas Movie she played "The Boss," aka God.